Ana Medina was born in Seville on May 5, 1942. She was married twice, and both marriages ended in divorce. She married HSH Prince Max Emanuel zu Hohenlohe-Langenburg, fifth child of Prince Max Egon zu Hohenlohe-Langenburg and Doña Maria de la Piedad Iturbe y Schlotz, Marquesa de Belvis de le Las Navas, at Seville on June 3, 1961. The marriage was dissolved by divorce in 1985. Doña Ana married for a second time on October 14, 1985 to Don Jaime de Urzaiz y Fernandez de Castillo. This marriage also ended in divorce. Prince Max died in 1994 and Don Jaime died in 2003.
She is survived by her three children, Prince Marco, Prince Pablo and Princess Flavia, seven grandchildren, her brother, Don Ignacio, Duke of Segorbe, and by her 95-year-old mother, Victoria Eugenia Fernandez de Cordoba y Fernandez de Henestrosa, Duchess of Mendinacelli.
Prince Marco will inherit his mother's titles. His elder child, Princess Victoria, is the heiress apparent. She and her younger brother, Alexander, live with their German-born mother, Sandra, in Munich.
Doña Ana was the eldest of four children of the 18th Duchess of Medinaceli and Don Rafel de Medina y Villalonga (1905-1992). Her brothers, Don Luis, Marque de Cogolludo, Duke de Santiesteban, and Don Rafael, Duke of Feria died in 2011 and 2001, respectively.